Tuberous sclerosis complex (TSC) is an extremely variable genetic disorder that can affect virtually any organ in the body. Disease manifestations continue to develop over the lifetime of an affected individual. Many manifestations can be life threatening; appropriate surveillance and management are necessary to limit morbidity and mortality in this disease. We report a case of an 8-year-old girl with TSC and bilateral renal cell carcinoma, which is usually thought to be a complication diagnosed in adulthood. Our report emphasises the need for frequent surveillance and renal imaging in paediatric patients with TSC.

The surface analysis of nanomachined AISI D2 tool steel materials is measured using atomic force microscopy. The surface roughness and fractal dimensional analysis are the important factors in nano tribology and evaluating the quality of nanomachined surface. Carbon nanotube increases the heat carrying capacity, thermal conductivity of the lubricating oil and thus prevents any damage to the work piece. The surface morphology of different machined surface was studied by Fractal Dimension analysis and roughness characterization was carried out. The results indicate that the fractal dimension changed according to the smoothness of the machined surface. The Power Spectrum Density (PSD) method based Root mean square (Rms) surface roughness was calculated for carbon nano tube based nanofluids in grinding process. The fractal dimension and roughness are decreased due to single wall carbon nano tube based nanofluids and smooth surface finish has been obtained.

Objective. Epithelioid glioblastoma is a rare morphologic subtype of glioblastoma that closely mimics metastatic carcinoma or metastatic melanoma histologically. All previous case reports of this unusual glioblastoma variant have been solitary lesions. We report here the first case to our knowledge of multifocal epithelioid glioblastoma mimicking cerebral metastasis. Clinical presentation. A 67-year-old man with a prior history of mycosis fungoides, a common form of cutaneous T-cell lymphoma, presented with memory loss and impaired peripheral vision. Two discrete brain lesions highly suspicious for metastases were identified by magnetic resonance imaging (MRI). Intervention. The patient underwent two separate craniotomies; both lesions were successfully resected in toto with an excellent post-surgical outcome. Conclusion. Epithelioid glioblastoma is one of the rarest morphologic subtypes of glioblastoma. Here we describe the first case to our knowledge of multifocal epithelioid glioblastoma that convincingly mimicked a secondary metastatic process. Multifocal epithelioid glioblastoma should be included in the differential diagnosis of patients who present with multiple discrete brain lesions. An attempt at gross total resection is recommended when anatomically feasible for definitive histopathological diagnosis and to improve progression free survival of patients who present with similarly ambiguous and potentially misleading multiple lesions.

Objetivo. El glioblastoma epiteloide es un subtipo morfológico poco común del glioblastoma que puede imitar al carcinoma o melanoma metastásico histológicamente. Todos los casos reportados de esta variante inusual de glioblastoma han sido lesiones solitarias. Presentamos el primer caso de glioblastoma multifocal epiteloide imitando metástasis cerebral. Presentación clínica. Varón de 67 años con historia previa de micosis fungoide, una forma común de linfoma cutáneo e células T, cuyos síntomas fueron pérdida de memoria y alteraciones del campo visual periférico. Dos lesiones sospechosas de metástasis fueron identificadas por resonancia magnética. Intervención. Mediante dos craneotomías independientes, ambas lesiones se resecaron in toto con buen resultado post-quirúrgico. Conclusión. El glioblastoma epiteloide es uno de los subtipos morfológicos mas raros de glioblastoma. Los autores describen aquí el primer caso de glioblastoma epiteloide multifocal con apariencia de metástasis secundaria. Este diagnóstico debe ser incluido en el diferencial de pacientes con lesiones multifocales. El intento de resección total se recomienda cuando éste sea viable para obtener un diagnóstico definitivo así como para mejorar la supervivencia libre de enfermedad en pacientes cuya presentación incluya lesiones múltiples que puedan dirigir a un tratamiento inadecuado.